Hi, I am not an expert on this subject but I have some info about it. Info is that: when an excitatory signal transmits through an axon, at the end of the axon at the pre-synaptic side also an excitatory transmission occurs to excite post-synaptic neuron. And according to the manuscript which I have read, if there is an inhibitory signal will be transmitted to the post synaptic neuron, at the beginning of the pre synaptic neuron there is an inhibitive signal that starts to radiate through axon and so at the end of the pre synaptic neuron there will be an inhibitive neurotransmitter will be released.

my question is that: a neuron how can know which process (excitatory or inhibitory ) signal has been transmitted through its axon to the end of axon (at the pre_synaptic side). Because the chemical process may label the process as inhibitive or excitatory but from axon hillock to the pre-synaptic cleft the transmission is electrical so how could it be differentiated. Is there an electrically coded transmission so at pre-syanptic side neuron will release inhibitive neurotransmitter or excitatory neurotransmitter.

Thanks,