I am conducting research on Type 1 Diabetes (T1D) and the effects of probiotic treatment on beta cell function and glucose regulation. In my study, I observed the following:
Diabetic Group: Increased GLUT2 expression/ Increased PDX-1 expression
Probiotic Treatment Group: Decreased GLUT2 and PDX-1 expression
I am particularly interested in understanding: What could be the underlying mechanisms causing increased PDX-1 expression in T1D, and how does this relate to insulin secretion or beta cell regeneration?
To effectively answer your question, one needs to understand the model of type 1 diabetes you are using. Are you using rats, mice, and how was type 1 diabetes created? Dysregulated PDX-1 functions are usually associated with type 2 diabetes, but in type 1 diabetes, PDX-1 is usually destroyed by autoantibodies. However, depending on the model that you are using, one would be inclined to agree with upregulation of PDX-1 expression following pancreatic beta-cell damage and the resultant increased insulin demand.
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