In your opinion, Does Aflatoxin B1 cause a mutation in BARCA1 gene and thus produce triple negative breast cancer?
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024316/&ved=2ahUKEwjq6v-lkrjpAhV0AGMBHdCzCm8QFjAAegQIBRAC&usg=AOvVaw3Y4brngDGud7DmVqadFTul
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024316/&ved=2ahUKEwjq6v-lkrjpAhV0AGMBHdCzCm8QFjAAegQIBRAC&usg=AOvVaw3Y4brngDGud7DmVqadFTul
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811406/&ved=2ahUKEwj9wP_rkrjpAhXQ0KQKHSiTD3IQFjAJegQIBRAB&usg=AOvVaw2V1P4yA05Ih6Y0RMl-LS0l
Article Effects of different mycotoxins on humans, cell genome and t...
https://www.researchgate.net/publication/313414696_Effects_of_different_mycotoxins_on_humans_cell_genome_and_their_involvement_in_cancer_Review
Good evening Dr.
https://www.researchgate.net/deref/https%3A%2F%2Fwww.google.com%2Furl%3Fsa%3Dt%26source%3Dweb%26rct%3Dj%26url%3Dhttps%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5811406%2F%26ved%3D2ahUKEwj9wP_rkrjpAhXQ0KQKHSiTD3IQFjAJegQIBRAB%26usg%3DAOvVaw2V1P4yA05Ih6Y0RMl-LS0l
Article Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hep...
Dr. Assist.Prof.Dr. Mays Hadi Jebur… thanks for this important question.
The wide range of adverse effects caused by aflatoxin assumption is named aflatoxicosis and has been reported in two forms:
(i) “acute intoxication” caused by short exposure to great amount of toxins and characterized by severe liver damage, jaundice, haemorrhage, oedema and eventually death; and
(ii) “chronic sublethal exposure,” which leads to immunosuppression, nutritional dysfunctions and cancer.
Among these toxins, Aflatoxin B1 (AFB1) is considered the most recurrent and also the most harmful. Its carcinogenicity and immunosuppression capacity have been extensively reported in all kind of animals, including Poultry، trout، cattle and rats with different incidence across species, gender and age.
Several in vitro studies demonstrated that the carcinogenicity of AFB1 is prevalently exerted upon activation by Cytochromes P450 (CYP450) in the liver and elucidated the mechanism of its toxicity.
Another toxin causing great concern is Aflatoxin M1 (AFM1), the principal hydroxylated metabolite of AFB1, found in milk (hence the designation M) of mammals fed upon contaminated feedstuff.
Carry-over of AFB1 as AFM1 in the milk of dairy cows has been established to range from 0.3% to 6.2% . However, AFM1 was also found in lactating mother’s milk. Several studies reported carcinogenic and immunosuppressive effects، similar to that of AFB1, on both humans and other animals, even if with a less potent effect
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024316/&ved=2ahUKEwjq6v-
Dear Dr.
Aflatoxins are fungal metabolites found in feeds and foods. When the ruminants eat feedstuffs containing Aflatoxin B1 (AFB1), this toxin is metabolized and Aflatoxin M1 (AFM1) is excreted in milk. International Agency for Research on Cancer (IARC) classified AFB1 and AFM1 as human carcinogens belonging to Group 1 and Group 2B, respectively, with the formation of DNA adducts. In the last years, some epidemiological studies were conducted on cancer patients aimed to evaluate the effects of AFB1 and AFM1 exposure on cancer cells in order to verify the correlation between toxin exposure and cancer cell proliferation and invasion. In this review, we summarize the activation pathways of AFB1 and AFM1 and the data already reported in literature about their correlation with cancer development and progression. Moreover, considering that few data are still reported about what genes/proteins/miRNAs can be used as damage markers due to AFB1 and AFM1 exposure, we performed a bioinformatic analysis based on interaction network and miRNA predictions to identify a panel of genes/proteins/miRNAs that can be used as targets in further studies for evaluating the effects of the damages induced by AFB1 and AFM1 and their capacity to induce cancer initiation.
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Article Mutational Signatures in Breast Cancer: The Problem at the DNA Level
https://cancerpreventionresearch.aacrjournals.org/content/11/2/103
BR
Hi
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Hi Dr.
https://www.researchgate.net/publication/317280243_Mutational_Signatures_in_Breast_Cancer_The_Problem_at_the_DNA_Level
Dear dr.
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Hi Dr.
can see this link
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024316/&ved=2ahUKEwjq6v-
Hi doctor
I think Aflatoxin B1 cause a mutation in BARCA1gene but this requered long periode
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Aflatoxin B1 and M1: Biological Properties and Their Involve...
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Hi Dr.
maybe see the following link
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
Metabolic Changes of Aflatoxin B1 to become an Active Carcinogen and the Control of this Toxin
https://www.longdom.org/open-access/metabolic-changes-of-aflatoxin-b1-to-become-an-active-carcinogen-andthe-control-of-this-toxin-1745-7580-10000104.pdf
Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development
Article Aflatoxin B1 and M1: Biological Properties and Their Involve...
MiR-25-3p Promotes the Proliferation of Triple Negative Breast Cancer by Targeting BTG2
Article MiR-25-3p promotes the proliferation of triple negative brea...
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