In which medium/solvent it is better to dissolve Epigallocatechin gallate (EGCG)?

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Vítor Spínola

Hi,

since its a polyphenol it should be soluble in polar solvents like water, methanol, ethanol.

Ranjith Arimboor

methanol, ACN

Sandip Pal

@Vitor...instd of bt being polyphenol quercetin doesn't dissolve in water!

Jack Silver

It'd be at least somewhat soluble in water.. I purified it in a gradient, eluted in mostly wate with some methanol.

http://www.isco.com/WebProductFiles/Applications/101/Poster_and_Paper_Reprints/Purification_of_Phenolic_Flavonoids.pdf

Ramkumar Ponnuraj

It is soluble in water. Enclosed an article which may help you.

Thank you very much all of you!

Somnath Chanda

just 05 sec microwave does wonder in dissolving green tea catechins in water at higher concentrations

Faeze Ghare Chahi

I dissolved it in DMSO do you think it will change its effects??

I don't think so

Hi there

I have a problem with EGCG, in setting up experiments to treat NALM-6 cell line with it, they don't dye with different concentrations. I can see its auto-oxidation after incubation in cell culture condition. and changing morphology of cells under invert microscope but MTT doesn't confirm my observations.

I was thinking that its related to DMSO.