In the living intact human (or mammalian) brain, what is the degree of uncoupling of oxidative phosphorylation from oxygen consumption?

12 December 2012 1 6K Report

This is a question of the in vivo situation: how efficient are mitochondria in vivo?

Nobody knows but circumstantial evidence suggests about 60%, meaning that only 60% of the oxygen consumption is devoted to ATP regeneration. The rest of the oxygen would then be used for heat and ROS generation.

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