Hello.

I evaluate factors affecting the synthesis of lipid liquid crystalline nanoparticles with 2^4-1 fractional factorial design.

After the ANOVA, I have two possibilities. The first model with fewer terms (only significant in terms of p-value) has a lower R squared (0.7541). On the other hand, I can choose a model with two additional insignificant terms, one suggesting interaction between factors, and this model's R squared equals 0.8676.

What is more correct to do? To choose the model with only significant terms but with a lower R^2, or the model with more terms, including insignificant ones, but a higher R^2?

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