Jakub Jagielski

9 Questions 47 Answers 0 Followers

Questions related from Jakub Jagielski

What is the state of art of the machine learning and AI in the design of experiment?

Is the machine learning and AI in the experimental design a thing?

26 June 2023 4,775 2 View

How do you deal with cytotoxicity in a factorial design?

Hello. I would like to ask, how should I incorporate the cytotoxicity as a response in the factorial design, since cytotoxicity depends on concentration? My only idea is to evaluate the IC50 for...

05 December 2022 8,017 2 View

When publishing or presenting results from factorial design and central composite design, which data is the most important to show?

Hello there! My question concerns three cases: scientific papers, doctoral thesis and simple presentations. Which data from design of experiment are necessary in each case, which are more than...

16 November 2022 3,093 3 View

In a fractional factorial design, should I choose a model with insignificant terms that gives better R squared?

Hello. I evaluate factors affecting the synthesis of lipid liquid crystalline nanoparticles with 2^4-1 fractional factorial design. After the ANOVA, I have two possibilities. The first model...

06 October 2022 343 3 View

How does the coded value of alpha (axial point) in the Central Composite Design affect the whole design?

Hello! I went through the 2 level factorial design to screen factors, and now I am moving to the characterization using CCD. The coded alpha value in Design Expert v.13 is set to ca.-1.4....

27 September 2022 7,663 4 View

What method would help me to quantitatively evaluate the tranparency of such samples?

Hello! I am looking for a simple approach to evaluate difference in transparency of samples such as depicted below. Thank you in advance!

15 September 2022 8,731 3 View

In a factorial design, if a hydrodynamic diameter is my response, should I use one measurement per experimental unit or the mean of 3 measurements?

Intuition tells me that using the mean of three measurements, which is characterized by a standard deviation already, will interfere with other statistics calculations and subsequently with...

12 September 2022 8,276 3 View

In DOE approaches, can I use "categorical" responses?

Let's say, I prepared nanoparticles. As a response I would like to use "stability over two weeks". Can one use such "categorical" response or needs to make it numeric anyway, say "% of diameter...

10 June 2022 3,928 1 View

What if any of DOE experiments failed?

I have designed the optimization experiment using Box-Behnken approach. What should I do if any of the factors combination fails, for example because the aggregation occurs. Should I review whole...

24 May 2022 9,581 2 View