Hi, I am currently conducting a survival study to investigate the role of several potential biomarkers as prognostic factors in certain cancer. First, I perform Kaplan-Meier analysis for all the biomarkers and other relevant clinicopathologic data. However, only one biomarker fulfilled the proportional hazard criteria from the Kaplan-Meier curve. Other biomarkers and clinicopathologic variables do not fulfill the criteria.
I am wondering, do I still need to proceed to Cox Regression analysis? Can I include the other biomarkers and relevant clinicopathologic data in Cox Regression, even though they do not fulfill proportional hazard criteria during Kaplan-Meier analysis? Thank you.
Your question does not make sense.run the model that you wish to run.then look at the schoenfeld residuals for lack of pattern. See the attached screenshot reference for full details. Best wishes David Booth