Not really. The XRD pattern comes from interaction of the x-rays with the electron density and since isotopes only change neutron numbers, the electron density is not affected. A small difference may be in the Debye-Waller factor an thus the width of the reflections because this factor comes from lattice vibrations and these are affected by a mass difference. However, for elements that are already heavy, the effect would be close to invisible and hydrogen, for which the change from H to D would be the biggest, is barely visible in XRD.

X-rays do not interact with the nucleus of atoms, X-rays scatter because of its interactions with electrons and the amount of electrons does not change when the isotope changes. So XRD patterns do not change at all if the only difference is the isotope ratio.