This might lead to segregation which results in non-homogeneity (heterogeneity) of the tablet content. The final result is a variation in the dose of the different tablets.
If the ratio of fines is more in your granules then the major problem that you will face is of weight variation and segregation during tablet compression.
Capping/Lamination of tablets, Sticking on tablets/engraved portion.
Flow issue from Hopper to tablets feed frame and lead to weight variation/ content uniformity of tablets depending on loading % of API, Flow issue can lead to hardness/ thickness issue.