If a part of a viral polyprotein is exposed in the cytosolic region of an infected cell, does that make them easy targets for host proteasomes?

25 May 2017 1 617 Report

In reference to this image provided in the link below, if the NS3 and NS5 portions of the dengue polyprotein is exposed in the cytosolic region of the infected host cell, does that make them prime/easy targets for proteolysis by host proteasomes?

https://www.nature.com/article-assets/npg/nrd/journal/vaop/ncurrent/images/nrd.2017.33-f1.jpg

Luis Del Carpio-Orantes

El blanco terapeutico en casi todas las estructuras virales es el NS2B-NS3. Aplicable al menos en dengue y zika

https://www.ecronicon.com/ecmi/pdf/ECMI-07-00199.pdf

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