By gaining a better understanding of the factors influencing permeability of our cell membranes, we might be able to devise safer and more effective therapies to counter both acute and chronic diseases afflicting humans. Systemic inflammation and infection are often associated with neurological damage to the brain, amongst other vital organs. Endothelial cells, immune cells, Toll-like receptors, cytokines, and chemokines are implicated, e.g. microglia, the "resident" immune cells of the central nervous system. Of particular concern, is an association of IL-16 elevation and Alzheimer's dementia. Multiple array screening of inflammatory biomarkers might now be applied to study the time course of cerebral hypoperfusion, metabolism, and histopathological spatial distribution of changes during sepsis. Clearly, research in this area is needed. The recent preliminary (interim) report of IL-16 elevations in a cohort of patients in temporal relation to having received mRNA vaccination and/or booster inoculations, needs prospective statistical validation. Epidemiological study of an apparent increased incidence of myocarditis, pericarditis, thrombotic events, autoimmune responses, brain infections, and cardiac arrests in elite athletes, might all be explainable in terms of the Sanarelli-Shwartzman Phenomenon ("SSP"), a.k.a. the Generalized Shwartzman Reaction ("GSR") which has been observed and studied for over a century. It is entirely possible that the SSP plays a central role in chemical evolution and maintenance of genomic stability in all life forms. In the midst of an ongoing, persistent global pandemic (SARS-CoV-2 and its variants), this is a discussion we really need to have. I've been thinking about this topic for over a decade, from the perspective of a biophysicist. A multi-disciplinary approach is urgently needed.
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