I did the synthesis of palladium and copper complexes with metronidazole as primary ligand and methionine or cysteine as a secondary one . Some related articles show that methionine is a bidentate ligand which binds to the metal through nitrogen and oxygen and other articles talk about N and S binding.
Mr./Miss/Mrs Tidjani,
Methionine, in particular, and methyonyl-containing peptides, in a more general context, exhibit a competitive coordination ability to large scale metal ions, involving N, O and S - centers. We have series of works on metal complexes (mainly transition metal ions) with methyonyl-containing peptides (eg. [Ref. 1], attachment), where the bonding is via S-center.
In this context, if you do not have the ability to isolate single crystal, allowing you X-ray diffraction structural study, you should obligatory conduct NMR (attachment) and tandem MS/MS mass spectrometric experiments in order to determine the coordination of (CH3)S. In the NMR, it is a very characteristic and intensive signal of CH3S- protons, which is significantly affected by coordination of S(CH3) group. The same is valid for MS/MS signals of fragment species containing M-S bonded complexes at low m/z values.
Mrs Bojidarka B. Ivanova
Thank you for the clarification you gave me on the coordination of methionine. Yes it's true that we NMR indicate the chemical displacement of sulfur-related protons.
Unfortunately, attempts to obtain a single crystal were unsuccessful.
Mrs Tidjani
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