To evaluate the efficiency of animal extract in the improvement of induced bone osteoporosis in laboratory animals so I need to know which substance can be used to develop bone necrosis within short duration and minimal side effect.
There are certain Glucocorticoids which are used for this type of study. You can select from a wide variety of them
Of course, glucocorticoid
Prednisone acetate at 1.5, 3.0, and 6.0 mg/kg/day by oral gavage respectively can induce osteoporosis in rats.
Prednisone also have other significant side effects like slowing down the kidney resulting in accumulation of fluid in different pats of the body.
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