There are certain Glucocorticoids which are used for this type of study. You can select from a wide variety of them

Of course, glucocorticoid

Prednisone acetate at 1.5, 3.0, and 6.0 mg/kg/day by oral gavage respectively can induce osteoporosis in rats.

Prednisone also have other significant side effects like slowing down the kidney resulting in accumulation of fluid in different pats of the body.