Please let me know if these references/sites are useful to you:

1.   Neuroradiology. 2016 Oct;58(10):961-967. Epub 2016 Jul 22.

Impact of leukoaraiosis on parenchymal hemorrhage in elderly patients treated with thrombolysis.

Nighoghossian N1, Abbas F2, Cho TH1, Geraldo AF3, Cottaz V1, Janecek E3, Mechtouff L1, Bischoff M4, El Khoury C4, Schott AM2, Derex L1, Hermier M3, Tisserand LG3, Amelie R3, Chamard L3, Berthezene Y5.

Author information

1

Department of Stroke, Neurological Hospital, Université Lyon 1, Lyon, France.

2

Pôle Information Médicale Evaluation Recherche, Hospices Civils de Lyon, Lyon, France.

3

Department of Neuroradiology, Neurological Hospital, Université Lyon 1, 59 Bd Pinel, 69677, Bron, Lyon, France.

4

RESUVAL Stroke Network, Lyon, France.

5

Department of Neuroradiology, Neurological Hospital, Université Lyon 1, 59 Bd Pinel, 69677, Bron, Lyon, France. [email protected].

Abstract

INTRODUCTION:

Severity of vascular damage of white matter may predict hemorrhagic transformation (HT). We assess the relationship between leukoaraiosis (LA) severity and the type of hemorrhagic transformation in elderly patients treated with thrombolysis.

METHODS:

We retrospectively analyzed the clinical data and pretreatment magnetic resonance imaging (MRI) of 180 consecutive ischemic stroke patients aged over 75 years. LA severity was graded according to the Fazekas scale, and acute diffusion-weighted-imaging (DWI) lesion volumes were semi-automatically outlined. Predictors of hemorrhagic infarction (HI) and parenchymal hemorrhage (PH) were identified using logistic regression analysis and exact multinomial logistic analysis.

RESULTS:

HT occurred in 31 patients (17 %). Baseline National Institute of Health Stroke Score (NIHSS; p = 0.008), severe LA (p = 0.02), and diffusion lesion volume (p = 0.02) were predictors of HT in univariable logistic regression. Adjusted to lesion volume and baseline NIHSS score, exact multinomial logistic analysis showed that severe LA was the only independent predictor of parenchymal hemorrhage (p = 0.03).

CONCLUSION:

In elderly patients, LA severity better predicts parenchymal hemorrhage than infarct size.

KEYWORDS:

Elderly; Ischemic stroke; Leucoaraiosis; Magnetic resonance imaging; Thrombolysis

2.  Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population.

Li Z, Zhong L, Gu L, Huang W, Shi X, Zhang X, An X, Lin Q, Tzeng CM.

BMJ Open. 2016 Jan 12;6(1):e009499. doi: 10.1136/bmjopen-2015-009499.

PMID:

26758262

Free PMC Article

The (2) article is freely downloadable at the following site:

http://bmjopen.bmj.com/content/6/1/e009499.long

Dennis

Dennis Mazur

Please visit this site and the abstract is in English.

http://www.pibb.ac.cn/pibben/ch/reader/create_pdf.aspx?file_no=20150322&year_id=2015&quarter_id=12&falg=1 

We have studied microvascular changes and white matter disease in dementia since many years (and we currently do). Please have a look at Haglund M and/or Sjobeck M with Englund E from years 2002 and on. If the info is in line with what you seek, I'll be glad to provide more extensive text. 

I think you should contact Prof. Carlos Cantú-Brito

kind Hernàn Gabrielli,

just in case it might be useful [just downloaded], best regards, Mauro Colombo

Geriatr Gerontol Int. 2017 Aug 4. doi: 10.1111/ggi.13142. [Epub ahead of print]

Association of subclinical carotid atherosclerosis with immediate memory and other cognitive functions.

Matsumoto L1,2, Suzuki K1,2, Mizuno Y2, Ohike Y2, Ozeki A2, Ono S2, Takanashi M2, Sawaki D2, Suzuki T2, Yamazaki T2, Tsuji S1, Iwata A1.

Author information

1

Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan.

2

Center for Epidemiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Abstract

AIM:

To clarify whether carotid atherosclerosis and its risk factors are associated with cognitive decline.

METHODS:

We evaluated 206 individuals who visited our center for health screening. We carried out physical examinations, blood tests, intima-media thickness (IMT) measurement by carotid ultrasonography, brain magnetic resonance imaging scanning and cognitive function assessments. A total of 30 individuals, who had significant cerebrovascular lesions detected in magnetic resonance imaging scans, were excluded. To detect early cognitive decline, we defined "cognitive impairment (CI)" when a patient satisfied at least one of three criteria. These were Mini-Mental State Examination score

Dear Mauro

Thank for the information Very usefull and clarifying.

Kind regards

dear Hernan, you're wellcome, best regards

abstract downloaded Yesterday from Lancet Neurology

Detection, risk factors, and functional consequences of cerebral microinfarcts

Susanne J van VeluwxSusanne J van Veluw

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, , PhD

,Andy Y ShihxAndy Y Shih

Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA, , PhD

,Eric E SmithxEric E Smith

Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, MD

,Christopher ChenxChristopher Chen

Memory Ageing and Cognition Centre, National University Health System, Singapore

, MD,

Prof Julie A SchneiderxJulie A Schneider

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA, MD,

Prof Joanna M WardlawxJoanna M Wardlaw

Centre for Clinical Brain Sciences and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK, MD

,Prof Steven M GreenbergxSteven M Greenberg

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, MD

,Prof Geert Jan BiesselsxGeert Jan Biessels

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands

Correspondence to: Prof Geert Jan Biessels, Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3508 GA Utrecht, Netherlands

, MD Correspondence information about the author Prof Geert Jan BiesselsxGeert Jan Biessels

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands

Correspondence

Correspondence to: Prof Geert Jan Biessels, Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3508 GA Utrecht, Netherlands

Email the author Prof Geert Jan Biessels

Published: 14 July 2017

DOI: http://dx.doi.org/10.1016/S1474-4422(17)30196-5 

Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the small size of these lesions, affected individuals can have hundreds to thousands of cerebral microinfarcts, which cause measurable disruption to structural brain connections, and are associated with dementia that is independent of Alzheimer's disease pathology or larger infarcts (ie, lacunar infarcts, and large cortical and non-lacunar subcortical infarcts). Substantial progress has been made with regard to understanding risk factors and functional consequences of cerebral microinfarcts, partly driven by new in-vivo detection methods and the development of animal models that closely mimic multiple aspects of cerebral microinfarcts in human beings. Evidence from these advances suggests that cerebral microinfarcts can be manifestations of both small vessel and large vessel disease, that cerebral microinfarcts are independently associated with cognitive impairment, and that these lesions are likely to cause damage to brain structure and function that extends beyond their actual lesion boundaries. Criteria for the identification of cerebral microinfarcts with in-vivo MRI are provided to support further studies of the association between these lesions and cerebrovascular disease and dementia.

 just downloaded in a free fulltext

best regards, Mauro Colombo

Thank you Mauro for your interest and aid

Kind regards. Hernan Gabrielli