Protein aggregation underlies several neurodegenerative diseases. The recent evidence suggests that in fact aggregated protein in the living cell can lead to cell death. I would like to know your ideas about the mechanism of this toxicity.
Dear Laleh,
As a Bachelor student I have worked on poly-Q protein aggregation that is known in Huntington's. The idea is that by slippage of DNA polymerase CAG repeat areas can become so large that the transcribed protein cannot function properly and cause problems when it needs to be degraded by the proteosome. Eventually these defective proteins form aggragates that sequester all kinds of essential proteins, depleting the cell of functional proteins. Its just a matter of time before the cell can no longer cope with its disfunctional content.
it's bad. it's corrosive. like bad ideas in society...they accumulate until society breaks down under the weight of dysfunction, then society degrades, falls apart and dies. Trump is the misfolded toxic protein that breaks the camel's back.
- Badges
- Science topic
- Similar topics
- Social Psychology
- Attitude