I have some experience in 3D printing, but bioprinters are a bit different. I have knowledge about a few:
EnvisionTEC 3D Bioplotter (Manufacturer and Developer Series), uses syringe-based extrusion with materials like hydrogels, silicone, hydroxipatite, titanium, chitosan. Price could be around $200,000 or more
http://envisiontec.com/3d-printers/3d-bioplotter/
Organovo NovoGen MMX, uses the same technology like the previous one but with cellular hydrogels only. I don't know if it is for sale, because Organovo uses it to produce bioficial tissues and sell those to drug manufacturers.
RegenHU 3D Discovery and 3D Biofactory, uses the same process as the two above but with materials like bioink and osteoink. Price could be around $200,000.
FABION 3D Bioprinting Solution, uses multiple technology like photocuring, electromagnetic and exrtrusion with material of type hydrogels and organoids. I'm not sure whether it is for sale. It is a Russian-based 3D Bioprinting Solution develped by Skolkovo.
Biobots BioBot1, uses syringe-based exrtrusion and blue light technology with materials such as agarose, collagen, alginate, polyethylene glycol. Price is around $10,000
https://biobots.typeform.com/to/qKiBJp
CELLINK Incredible, uses syringe-based extrusion with it's own materials (CELLINK+, CELLINK A). Price is around €5,000-€9,000
http://www.cellink3d.com/
Ourobotics Revolution, uses syringe-based extrusion with collagen, gelatin, alginates, chitosan and other. Price is around €12,500
https://www.weare3dbioprintinghumans.org/
Advanced Solutions BioAssemblyBot, uses six-axes syringe-based extrusion and cost around $160,000
http://www.bioassemblybot.com/
GeSim Bioscaffolder 2.1, uses syringe-based extrusion and piezoelectric nanoliter pipetting with materials such as polymers, high viscosity paste materials, alginate, calcium phosphate, silicon, cell and protein solutions. Price is around $180,000
3Dynamic System - Alpha & Omega, uses syringe-based extrusion with bone tissue from PCL, PLA, PGA, PEG, fibrin elastin, collagen, calcium phosphate and hydrogel mixtures. Price is at least £12,000
Bio3D SYN and Explorer, uses syringe-based extrusion with polymers and hydrogels
n3Dbio Bioassembler, uses magnetic levitation with cells. They deliver it in kits with a price range from $500 - $750
I would recommend not going for the Cellink Inkredible/Inkredible+; we have 2 and though their design may be aesthetically pleasing the quality of their printing is not. All they can print is the training ink, Cellink Start which seems to be a mix of Pluronic F-127 and nanocellulose, which is only useful as a sacrificial ink.
Ozbolat et al. did an evaluation of a couple of different printing platforms in 2017, but the field moves so quickly that it is a bit dated now: Article Evaluation of bioprinter technologies
If you have a clear idea of what materials you would like to print and can provide sample inks, I would recommend Regemat3D. They will tailor one of their printers for your application for a similar price.
I have been having surprisingly good quality prints recently using the highly inexpensive Tissue Scribe (http://3dcultures.com/). This seems to be a retrofitted Monoprice Select Mini, but its well done. Once you get the hang of leveling it, and if you are a little bit savvy with writing g-codes, you can do quite a lot with this single nozzle unit.
I have been using Hyrel3d printers and they are very sufficient, reliable and multi-tasking printers. I encourage you to check them out, they are located in Atlanta, Georgia, USA.
I've been installing and supporting GeSiM BioScaffolders since 2016 and the price Dr. Radakovic is mentioning is too high - he must have gotten all the bells and whistles - of which there are a lot. You can get a BioScaffolder for way less than that. In fact I had customers that bought two BioScaffolders for the price of one RegenHU or EnvisionTec. GeSiM has so many cool new tools and accessories. They are an engineering firm that has been making solid products for two decades and they can create custom solutions for your application. If crude hydrogel blocks are all you need, then one of the little Cellink or Allevi boxes is probably sufficient. But once people get used to the level of control and the quality that GeSiM offers those feel like cheap plastic toys. Look up https://gesim-bioinstruments-microfluidics.com/ and contact me if you have questions.
Dear @Holger Pils, my answer dates back 3 years, while yours only 1 day. Those prices were offered to my school at that time. I'm sure you are aware that technology is rapidly developing, and prices have dropped since then. Also, new models have been developed in the meantime. It seems senseless to argue on a price dated back 3+ years ago opposed of today. Anyway, thanks for sharing that prices have gone down (and how much is it today?) Cheers!
, If you already have a printer and controller you might want to look into adding a piezo pipette to it. GeSiM offers a variety of piezo pipettes that can expel droplets in a range of 60-400 pL (yes, pico-liters). These would allow ink-jet printing and heated versions are available. These pipettes are typically used for micro-array printing on GeSiM's Nanoplotter but are also a feature of the Bio-Scaffolder. The Multi-Dos System (link below) allows developers to build their own dosing/printing solutions. Contact me if you would like to bounce around some ideas or if you are interested in pricing and visit www.scie-con.com.
The devices of all classes (cheap or expensive) have pros and cons. Additionally, if you do deep research you will notice that they differ from each other on many issues. It would be like comparing apples and oranges if you look from only one direction. For example, even though both companies have devices with 6 bioprinting heads, Envisiontec uses magnetic linear motors but Cellink still prefers stepper motors. Some of them have unique properties, for example, RegenHU has very nice patents such as melt electrowriting. Some of them have many small printbed and volume so you can only use well plates and petri dishes and cannot 3D print a bone substitute matching to the defect of a patient. Many of them use software that still need much more development. Therefore, you need to choose wisely according to your application and of course budget.
My first experience with my first 3Dprinter was very bad (a lot of air leak problems and very bad Z-axis motion control). However, on my second attempt, I received a proforma offer from a well-known company. Since it was very expensive, I found a company that manufactured me a custom made 3D bioprinter very very cheap, it is now running very smoothly, even better than a popular device at doing the same task.
Hello Dr. Yilmaz, you evidently did a lot of comparing. Thank you for sharing your thoughts! What would be a generally acceptable build size for your field? In which ways did the software lack the functionality you need?
Can anyone please tell the cost of low cost 3D bioprinter? And also if its possible to print on polymer sacffold using the ordinary 3D printer or ink jet printer?