I am starting a project on docking of cancer cell receptor by using plant drugs. Before starting that I wanted to know receptors which are present in the cancer cells.
There are no cancer receptors per se. These receptor may also be present on normal cells, perhaps in different quantities and under developmental control. Take HER2 for an example that receptor is just over expressed. It is also present and useful in normal cells.
To find targets like this just look for MABs Monoclonal antibodys and see what they target. e.g.. Erbitux aka Cetuximab... look for the MAB ending.
There are many receptors of the cancerous cells which can be targeted by the drugs G protein-coupled receptors, Estrogen Receptors, progesterone-receptors etc
Yes I agree with Govinda,
Gowri Shankar if you search in PubMed or even in google you will get many articles and you will also get more information how these receptors can be blocked and their different characteristics more in depth.
So I think you just have a survey for article and read out as much you can.
Thank you.
There are no cancer receptors per se. These receptor may also be present on normal cells, perhaps in different quantities and under developmental control. Take HER2 for an example that receptor is just over expressed. It is also present and useful in normal cells.
To find targets like this just look for MABs Monoclonal antibodys and see what they target. e.g.. Erbitux aka Cetuximab... look for the MAB ending.
Notch receptor and TLR receptor are some of the most common ones. Faulty regulation of the Notch receptor is implicated in many T-ALL (T-Acute Lymphoblastic Leukemia) which is a very common form of blood cancer.
You also have a different approach: many natural products, specially macrocyclic diterpenes inhibit P-gycoprotein, one of the major causes for Multidrug Resistance (MDR). This phenomenon has been increasing in the last years, so it's a very interesting subject.
Gowri Shankar, The cancer receptors may first have to be identified. Some receptors like the estrogen, progesterone receptors and G-protein-coupled receptors have been identified and various drugs have been targeted towards those receptors. But since you are interested in plant-based drugs you may study the molecular mechanism of action of Vincristine, Vinblastine and curcumine and find out the respective receptors involved. Good luck on this interesting project.
but there is a site you can have access to find the quantity of receptors on the different type of cancer cells. unfortunately i can not find that.
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