I want to use pure ibuprofen on experimental animals.How to dissolve it for dosing? In one paper they mentioned CMC solvent.

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Dr. Pracheta *

Hello Abid Ali Sir!!

The solubility of ibuprofen in 15 different solvents including water and at temperatures ranging from 15 to 60 degrees is given in the article given below. This large volume of very useful data is plotted so that it is easy to compare the solubility in one solvent to that of another solvent. Hope this article solve your quarry.

Lee, T.; Kuo, C. S.; Chen, Y. H. Pharmaceutical Technology, October 2, 2006

This article can be found at

http://pharmtech.findpharma.com/pharmtech/article/articleDetail.jsp?id=378746&sk=&date=&pageID=3

Maria Gonzalez-Rey

I would recommend you to buy it from a credible brand...Brufen as excipients such as: modified corn starch, croscarmellose sodium or other agents such as: titanium dioxide...

I also used IBU for oxidative stress assays ...see one of my articles.

Gonzalez-Rey, M. & Bebianno, M.J., 2012. Does non-steroidal anti-inflammatory (NSAID) ibuprofen induces antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis? Environmental Toxicology and Pharmacology 33(1), 361–371. doi:10.1016/j.etap.2011.12.017

Abid Ali

Its an interesting publication can u send me a full text of this paper it will help me a lot. [email protected]