Dear Manizheh Khanian Najaf-Abadi the industrial production of choline chloride involves the reaction of hydrochloric acid, trimethylamine, and ethylene oxide (see attached diagram) according to the link cited below:

Choline Chloride

https://web.archive.org/web/20140918142932/http://www.davyprotech.com/what-we-do/licensed-processes-and-core-technologies/licensed-processes/choline-chloride/specification/

The reaction initially involves the formation of trimethylamine hydrochloride, followed by insertion of ethylene oxide into the N–H bond. Basic information about the manufacture of choline chloride can also be found in the respective Wikipedia entry at

https://en.wikipedia.org/wiki/Choline_chloride#cite_note-3

I hope this helps. Good luck with your work and best wishes, Frank Edelmann

Dear professor Frank Edelmann

Thanks a lot of for you consideration

Also, I am really grateful for all the information you kindly shared with me.

What is matter for me, is the quantities of hydrochloric acid, trimethylamine hydrochloride and ethylene oxide required to make choline chloride.

I mean I am engaging with the mass balance of this reaction.

If possible please help me to solve my problem.

With kindest regards,

Manijeh

Dear Manizheh Khanian Najaf-Abadi thank you for your kind response and explanation. As for the quantities of hydrochloric acid, trimethylamine and ethylene oxide required to make choline chloride just check the Wikipedia entries of the individual compounds for their molar masses. Then consider that the reaction proceeds in a molar ratio of hydrochloric acid : trimethylamine : ethylene oxide = 1:1:1. Please note that trimethylamine hydrochloride is the reaction product of trimethylamine with hydrochloric acid (Me3N + HCl gives [Me3NH]+Cl–). Thus instead of trimethylamine and hydrochloric acid you could also use pre-formed trimethylamine hydrochloride as starting material. For some more detailed information about this reaction please have a look at the following relevant reference:

A Kinetic Model of the Choline Chloride Synthesis

Article A Kinetic Model of the Choline Chloride Synthesis

Unfortunately this article has not been posted as public full text on RG. Perhaps you can access it through your institution.

Good luck with your work and best wishes!

Dear professor Frank Edelmann

How kind you are to help me.

Thanks a lot of for your help.

I wish you many years of happiness!