I want to develop an amino acid (L-arginine) conjugated carbohydrate polymer by the reaction of -OH group and -COO group. How could I proceed?

09 August 2022 1 8K Report

Kurt Wachholder

You could try to protect the primary amines with benzyl chloroformate first. Then use a carbodiimide (like DCC, DIC, or 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) to form the ester with the -OH of the carbohydrate. You may need to use a benzotriazole (like HOBT) with the carbodiimide to minimize racemization. The protecting groups are then cleaved by hydrogenation.

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