As the name suggests COMSOL Multiphysics is capable of handling multiphysical modelling and has a very user friendly UI. Here is an application example from their site but I'm sure there are others: https://www.comsol.com/model/single-edge-crack-988
Multi-physics problems can defenitely be easily solved through COMSOL multiphysics software. Various physics could be easily added to solve any system with involvement of their domain equations