I am planning to prepare Synopsis for Randomised Controlled Trial with Clinical Superiority Trial. I want to compare the Periapical Healing Outcome of Sealapex vs Endosequence BC Sealers. Primary Outcome is Post Endodontic Treatment Decrease in periapical radiolucency. There are currently no Human Studies available, but Limited Animal Studies are available in literature. I'm having difficulty in calculating the Sample Size for my Clinical Trial among Humans.
Please Guide.