Dear Ali,
Hi
You can go through a literature survey mentioning LSD1 inhibitor and cancer as well as BRD4 inhibitor in cancer .
Hope you will get an idea about your question's answer
West of luck
Anuj
Hello Ali,
Can you be more specific in your query? If you just needed overview, you can go through this article:
Cancer epigenetics: linking basic biology to clinical medicine. Hsing-Chen Tsai and Stephen B Baylin, Cell Research, 2011.
cheers everybody ; my title is
Changes in DNA methylation during carcinogenesis – explain how DNA methylation can play a role in the development of cancer ..
give best examples and ask Qs ?
You might have heard about gene vs environment..With respect to your query, in short DNA methylation constitutes a major part of the environment. It is a natural process that occurs across the genome. If DNA methylation occurs abnormally(either hyper/hypo methylation) in the promoter region of critical genes involved in cell cycle. It will lead to changes in gene expression and thereby carcinogenesis will be triggered.
Hello Ali,
What is your specific query? From what I understand, you only want to know the role of DNA methylation in Carcinogenesis. So, I guess you know that DNA is continuously exposed to various environmental factors (reports state the amount to be about 100000 lesions per day in each cell) that may cause DNA damage, which are consistently repaired by the DNA repair mechanisms. Among them, one such factor is methylation across the genome. If this occurs persistently in the CpG islands of the some important genes and goes unrepaired, it leads to altered regulation of cell cycle leading to trigger of carcinogenesis.
Dear Ali,
The following headlines may help you in your research.
The role of epigenetic complexes in DNA methylation and carcinogenesis
Oncogenic long non-coding RNAs (lncRNAs) and DNA methylation
Down-regulation of tumor suppressor genes expression through DNA methylation
Up-regulation of oncogenes expression through DNA demethylation
I hope this helps.
Best,
Abbas
Is not so new but this book can help you https://www.crcpress.com/Epigenetics-in-Biology-and-Medicine/Esteller/p/book/9780849372896
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