27 January 2017 2 613 Report

I am planning a study using an anesthetized pig model to better understand bladder filling and motion. From the literature, it seems that urethane would be the best anesthetic for the study, because it does not change the bladder motion or bladder capacity as much as other anesthetics. In the literature, I've seen many different administration methods used, so would you recommend a slow, IV drip or a large bolus at the start of the study? If we do the large bolus (~1.2 g/kg seems common), who long does it last in a pig?

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