I am doing a systematic review and meta-analysis for somatic and germline mutations. I hoever need information on how to assess the somatic mutations (extraction and quality assessment). I am struggling to get this information from literature.
Supposing you have included non-randomized studies, your quality assessment part should follow a structured questionnaire, a popular example is the Newcastle-Ottawa Scale. This scale looks into the methodological aspects of each study (eg. Comparability of patient and control group). Im not sure about your question on data extraction, could you elaborate?