Recent therapeutic researches in oncology and neurodegenerative disorders, have focused on the inhibition of TDP1, but it seems that the science community is going in the wrong direction.
Consider these statements:
" Accumulation of mtDNA damage has been involved in neurodegenerative disorders (Parkinson, Alzheimer’s, and Huntington diseases), myopathies and diabetes, and has been associated with aging, cancer, and age-related degenerative disorders."
" mitochondrial base excision repair depends on TDP1 activity and provide evidence that TDP1 is required for efficient repair of oxidative damage in mitochondrial DNA."
" The ability of TDP1 to resolve 3′-phosphotyrosyl linkages is consistent with its role in protecting cells against Top1-DNA lesions."
Can someone explain further, inhibition or activation of TDP1?
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