Hi,
I am working on a project which is analyzing the effect of exercise on the HPA axis markers and the second aim is to see whether a change in markers after exercise is correlated with a mental health questionnaire. I didn't get any significant change in markers but still, I got a correlation with mental health questionnaire domains. Like a positive correlation between cortisol and depression. What could be the possible explanation for this? or are these results just random and not relevant?
Check this out if it helps you.
doi: 10.1017/S0033291712000955. Epub 2012 May 8.. 2013 Mar;43(3):449-69.Psychol Med
Cortisol and depression: three questions for psychiatry
J Herbert
We put parkinson's (PD) models (mice) through exercise in a running wheel and the mice showed beneficial changes after exercise.
what type of exercise? Was there a specific testosterone laboratory collection? what kind of template are you using?
Lendo novamente ambas as discuções que vc postouvamos pensar o seguinte:
o estresse genericamente não se caracteriza nem, como bom (um evento positivo), nem como deletério; ele é simplesmente uma respostaem função de alguma coisa.
entao vamos pegar um trecho do meu artigo, que diz o seguinte:
stress is all exogenous cause and effect thatphysiologically are neuroimmunoendocrine triggers of cognitive-dependent response, which allostatically lead the system tohomeostasis by nature regardless of the cause of its damage, beit benign and/or deleterious, in the acute form ofbioinformational character and in the immunopathogenicchronic form (PDF) IMMUNOSUPPRESSION CAUSED BY EMOTIONAL STRESS: FROM ETIOLOGY TO PATHOGENESIS. Available from: https://www.researchgate.net/publication/363173341_IMMUNOSUPPRESSION_CAUSED_BY_EMOTIONAL_STRESS_FROM_ETIOLOGY_TO_PATHOGENESIS [accessed Jun 19 2023].
ele é um mecanismo de resposta. quando esses marcadores cortisol catecolaminas preparam o "tecido" que vai lutar ou fugir, (fenomeno de luta ou fuga. e juntamente com a e juntamente com a testosterona e alguns outros marcadores, participam do processo de cognição e julgamento, por isso gerou essa resposta positiva mesmo em paciente com um espectro de ansiedade ou depressão.
e se voce aplicar o mesmo teste, por exemplo um dia depois o comportamento dos paraqmetros de resposta dados pelo paciente tente a ser mais positivo, porque esse tipo de resposta é dependente das experiencias, ou seja cognitivo-dependente.
Mikulska et al. (2021):
"The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic stress, which plays a key role in the pathophysiology of depression. Overactivity of the HPA axis occurs in major depressive disorder (MDD), leading to cognitive dysfunction and reduced mood. There is also a correlation between the HPA axis activation and gut microbiota, which has a significant impact on the development of MDD. It is believed that the gut microbiota can influence the HPA axis function through the activity of cytokines, prostaglandins, or bacterial antigens of various microbial species. The activity of the HPA axis in schizophrenia varies and depends mainly on the severity of the disease."
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