Recently while studying an article on bone matrix i read that presence of woven bone is always abnormal in an adult,but can be found in fracture repairing bone. It means that when newly synthesized collagen fibres are entangled in each other like wool but later they convert into lamellar pattern. Mechanism behind this conversion?
After a fracture, the initial repair produces woven bone that will be remodeled. The process of bone remodeling which involves the resorption (of the woven bone) and then the formation of new bone will allow the progressive replacement of woven bone in lamellar bone. The orientation of the collagen fibers is at least in part related to the mechanical loading applied to the bone to fully restore its biomechanical properties.
The woven bone is indicative of rapid and uncontrolled osteoformation associated with a high level of remodeling (the bone is being produced too fast) as can be seen in the repair of a fracture (callus formation). Replacement by lamellar bone can take time (from a few months to years).
See ref: “The biology of fracture healing” by Marsell R, Einhorn TA. Injury. 2011 June ; 42(6): 551–555. doi:10.1016/j.injury.2011.03.031.
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