I have a small query regarding how you have calculated the predicted value of % HIA  of individual drugs like Paracetamol, Nicotinic acid, etc.

I didn't understand what equation suggested in the research articles,

can elaborate in detail?

some researchers suggested that it will be calculated based on compound nature, like Molecular weight, pka, H-bond, H-ion acceptor, H-Ion doner, etc

I need an equation, on how to be will calculate the predicted % HIA for a specific drug?

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