I have a small query regarding how you have calculated the predicted value of % HIA of individual drugs like Paracetamol, Nicotinic acid, etc.
I didn't understand what equation suggested in the research articles,
can elaborate in detail?
some researchers suggested that it will be calculated based on compound nature, like Molecular weight, pka, H-bond, H-ion acceptor, H-Ion doner, etc
I need an equation, on how to be will calculate the predicted % HIA for a specific drug?