some drugs are fat soluble and do not dissolve body fluids. before using them, an additive such ac detergent is used to mix them well. but if a drug is too hydrophilic, how to make them soluble in oil?
the carrier oils and additives can have unpleasant side effects, trigger allergic reactions and be painful to inject, while the soluble-particle approach requires a complicated manufacturing process.. For example, patients in intensive care who receive the sedative propofol in soybean oil for long periods of time may develop dangerously high levels of fat in their blood. If propofol could be dispersed in water using the ultrasonic technique, that side effect would be eliminated. With this technique , penetration coefficient and solubility are increased
Dear all,
there a lot of work on this topic to use double hydrophilic polyethylene glycol diblock copolymers to encapsulate hydrophobic drugs. Regards
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