Mechanism of Drug action (MOA) is central to the understanding of the pharmacodynamics concepts. A thorough comprehension of this concept can reinforce the advanced level of practice and acquisition of skills linked to the pharmacotherapeutic management of drugs. Improvement of which broad level or practice concepts are linked to the understanding of drug mechanism of action?
Although I didn't get a single reply to this question for the last 5 days. My own quest to this line of inquiry took me to an interesting study titled ' Adverse drug reactions reporting by undergraduate medical students in a tertiary care teaching hospital of India by Patel et al, 2017.
They mentioned that undergraduate medical students reported a high frequency of Adverse drug reactions (ADRs) with a single drug suspect and probable causality. Moreover, the ratio of augmented (dose-related) to bizarre (non-dose related) reactions was higher among students’ reporting. Students could have easily correlated the augmented type reactions with mechanisms and pharmacological actions of the drugs.
Through this example, we came to know that how understanding the mechanisms of drug action impacted medical students ways of thinking and practising and fostered pharmacotherapeutic skill such as Adverse drug reaction (ADR) reporting.
Reference:
Patel PB, Patel TK, Anturlikar S, Khatun S,Bhabhor P, Saurabh MK. Adverse drug reactions reporting by undergraduate medical students in a tertiary care teaching hospital of India: Content and quality analysis in comparison to physician reporting. Perspect Clin Res 2017;8:137-44.
Thanks, Tony, I agree with you. It is worth appreciating how this only component of the overwhelming wealth of pharmacology knowledge impact health professionals ways of thinking and practising in the domain of pharmacotherapeutics. The coupling of knowledge with the clinical experience reinforces the advanced level practice, it is where the knowledge and its application shape up the mastery of an expert.
We are working on concepts having a threshold trait that bridge the fundamental/core level concepts with the advanced level practice & mastery.
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