Hi, I am trying to synthesize Schiff base by using benzaldehyde and primary amine of pyrimidine.
I used CH3OH, C2H5OH, as a solvents and glacial acetic acid as a catalyst.
But unfortunately reaction does not proceed
Please give me a solution on this.
Pyrimidine doesn't have a primary amine. The ring is aromatic so won't react in this way.
Did you mean a derivative of pyrimidine?
There are a number of microwave options for Schiff bases as well.
There is also the possibility if using potassium alum as a catalyst.
See the following paper..... SYNTHESIS, CHARACTERIZATION AND REGULATORY ASSESSMENT OF SCHIFF’S BASES USING ALUM [KAI (SO4)2.12H2O] AS AN EFFICIENT AND NOVEL CATALYST
Substrates in THF (or MeCN for ex.) and molecular sieves could be better choise
Thanks for the suggestion Carlos F. Marcos, may i know how much equivalence of anhydrous Na2SO4 shall i use.
If you have any reference for above suggestion then please send me.
After the successful trial and error method, i come to know that in alkaline condition these reaction goes. So i added the alc. NaOH solution and i got the product.
@prasad Dhiwar
Please describe your product separation method and the purity of compound
Their is a no method as such for separation like extarction.
The purity of compound is confirmed from LCMS.
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