Dear Sonal,

For hydrophobic drugs I suggest to use the same delivery system utilized for Cinchocaine (INN/BAN) or dibucaine. The delivery system is liposomes which can be prepared as follows:

Liposome preparation

Multilamellar liposomal vesicles (MLVs). – MLVs containing the drug are prepared according to the classical method of Bangham et al. (3).

The lipid components egg phosphatidylcholine (EPC), either alone or in different

molar ratios with cholesterol (CHOL), and either stearylamine or dicetyl phosphate (DP) are weighed into a long-necked pear-shaped quick-fit round bottom flask and dissolved in chloroform/methanol (7/3, V/V). The drug is dissolved in the same solvent mixture and be added to the lipid solution. The organic solvent is removed under reduced pressure at 55 °C using a rotary evaporator. The resulting

thin lipid film is slowly hydrated using bicarbonate buffer pH 9.0. IThe process of

hydration was carried out by rotation at a low speed at 55 °C in a rotary evaporator under atmospheric pressure followed by hand shaking for 15 minutes at 55 °C in a thermostatically controlled water bath. The resulting liposomal dispersion is left to mature overnight at 4 °C.

I suggest that you read the attached paper which describes the details of the above mentioned procedure.

Hoping this will be helpful,

Rafik

thank you 

I hope that following paper answer your question.plz check out

Regards

 thank you sir for such a useful paper