As i have read in many papers that HCT -116 is an colorectal carcinoma while HT 29 is colon adenocarcinoma. Can someone plase explain the diferrence?
Carcinoma is the form of cancer originated from epithelial cells. Adenocarcionoma is a type of Carcinoma originated from glandular epithelial cells. Most of CRC patients have Adenocarcionoma.
Correct. There are some entities however, of colorectal carcinoma that do not precisely fit this description - a basic way of conceptualising this is as follows - cancer cells, the more differentiated they are, the more they feature elements of the tissue they are from. Therefore a well differentiated adenocarcinoma would have features of the glandular epithelial cells Swaroop has mentioned. An undifferentiated or poorly differentiated carcinoma would have cells that do not really follow features of glands etc - in some cases, the carcinoma can be so undifferentiated, it is difficult to classify as epithelial origin at all. On occasion, colon carcinoma can even resemble sarcoma too. We recently encountered one of these rare entities [carcinomatoid sarcoma], and had the case presented at the ASGBI - link as follows for your review - https://epostersonline.com/asgbi2018/node/2393
Hope that helps....Professor Singh-Ranger
HCT116 and HT29 are both colon cancer cell lines. HT29 cells are more adhesive than the other types.
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