Dear RG members,
pl provide some information regarding how to separate a mixture of 4-nitrobiphenyl and 4-nitrobromo benzene as they both have same Rf in EA, Hexane, DCM, PE, diethylether, MEOH and a mixture of EA/Hex, Hex/DCM, PE/Hex, PE/EA, Diethylether/Hex, Diethylether/EA with various proportion. Literature reports the clean NMR of Biphenyls from Suzuki Coupling reaction. can anyone help me to separate these products. In TLC plate both 4-nitrobiphenyl and 4-nitrobromo benzene have single spot. but crude NMR consists Peaks of both reactant and product.
Try using toluene. I've had luck separating hard-to-separate phenyl-based compounds with toluene and EA. Could also try using a different phase like alumina
I think you can use multi solvent for tlc solvent and then you will get rf value different
Regards
Already tried a lot of single and multi solvent. Also tried toluene. But there is no separate spot observed.
Hi Rayasingh,
You can try more solvents or solvent mixtures. Or use extraction, recrystallization and vacuum distillation instead of TLC.
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