I work on microfluidic device, and recently I have to use microsphere to learn the concept of blood flow, but I have no idea on how to separate the 4um and 10 um microsphere into different region. Does anyone have idea?
¿Could you be more specific? I do not understand the meaning of "separate" in your model
Depends somewhat on the stock concentration (solid contents of the microspheres). Settling/sedimentation is definitely the way to go if you have reasonable number of microspheres. If it is too dilute/small sample size you can try a flow cytometer with particle classification capability. Filtration using controlled pore membranes maybe possible though I am not sure if an appropriate cutoff will be readily available. There are more exotic approaches available for example dielectrophoresis.
Hi,
One 'exotic' way is inertial microfluidics if you need/want to do it under flow. There is a substantial number of papers on how to use inertia to separate paricles of different sizes. Reading Dino Di Carlo's papers is a good way to start.
Best,
S
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