I am preparing a film containing asenapine maleate. How should I select the composition of the dissolution medium?
You've to perform the dissolution in artificial saliva pH 7.0 USP
Agree. Use a buffer that has pH of saliva
Exactly, salivary pH is required as media. mean values of 6.97 and 7.40 for unstimulated sliva and Stimulated sliva respectively (range US: 6.49–7.28, range SS: 6.96–7.69.Choose any PH and provide justification.
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