In dissolution study of gastro retentive tablet , How to select dissolution fluid and their volume if drug's formulation is not official in pharmacopoeia.
Hi Vipul,
In general, to test dissolution studies of any oral dosage form, researchers use pharmacopoeia reference / in-house techniques (which depend on your formulation type-whether tablet/capsule/nano/micro particles/emulsion etc; the volume of media-from 20-900 ml; type of technique-centrifugation/dialysis/dissolution chamber usage etc).
I would suggest, for your GRDDS, as this type of system is specific to stomach, so, mimic simulated acidic conditions using, 900 ml of 0.1 N HCl (pH 1.2), at 37±0.5, stirring speed of 50 rpm. And, keep the same conditions for all the test groups and find a proper quantitative method for your drug by photometric/fluorimetric/HPLC.
These might be useful,
https://www.ncbi.nlm.nih.gov/pubmed/16506949
http://www.sciencedirect.com/science/article/pii/S1818087613000263
https://www.ncbi.nlm.nih.gov/pubmed/24440665
For gastro retentive preferable medium is acetate buffer pH 1.2 or 0.1 N HCl as gastro retentive we assume to be used in the empty stomach conditions. Volume of dissolution medium you can select on the basis of drug content of your formulation means the concentration of drug in each collected sample should be sufficient enough for the detection thorough your analytical method. Secondly, we should try to correlate with the empty stomach conditions (specially volume).
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Medical Pharmacology
- Clinical Pharmacology