TiCl4 is often used as a Lewis acid catalyst in organic reactions. Removing it from the reaction mixture is important to avoid unwanted side reactions and improve the quality of the final product. Here are a few methods to remove TiCl4 from an organic reaction mixture containing a peptide product:

It's important to keep in mind that the specific method you choose may depend on the solubility and reactivity of the peptide, as well as the conditions of the reaction mixture. In general, it's a good idea to consult the literature or consult with an expert to determine the best method for your specific situation.

To separate the peptide from the organic mixture containing TiCl4 and remove the TiCl4, you can consider the following steps:

Note that this is a general outline and the specific conditions and methods may vary depending on the nature of your peptide and the conditions of your experiment. It's always advisable to consult the literature and perform a trial run to optimize the conditions for your specific case.

Of all the earlier suggestions, only Geir Bjorklund's proposal (3rd basic workup) is the safest. I do not recommend column purification or evaporation of the reaction solution without first destroying the TiCl4.

https://www.youtube.com/watch?v=bR_LAr_mOCw

Thank you one and all for your valuable suggestions Geir Bjorklund Ahmad Al Khraisat Goran Benedeković

I may work according to the safest way which is suitable for my reaction condition. I am eExpecting your suggestions throughout all my discussions.

Thanks

Dr. S. Balachandar

Thanks for sharing such an useful video about TiCl4 chemical properties Goran Benedeković