We use the LC/QQQ for detecting PFOS, PFOA and other pharmaceutical compounds. When we run the blank sample (methanol), the peak of the compounds were detected with very high value, suggesting there is contaminant in the needle of sampler or mass spectrometer. We clean needle many time using methanol and the chamber of MS but it doesn't work.
Could you please suggest me how to clean the contaminants in MS?
Pham,
If you are having issues with PFOA/PFOS contamination -
If your system has any teflon tubing (like all your solvent lines) - you will need to change them all out to PEEK. Also use an isolator column pre-injector to trap system contaminants.
Message me direct if you want to talk I run this analysis on a routine basis in my lab (LC/MS/MS).
Hi Peter,
Thank you so much for suggestion. I check our LC/MS systems. The tubing seems to be a Teflon one. Would you mind giving me your email address so that I could discus you more about this problem?
Hi Peter,
For mobile phase, we use HPLC grade solvents no LC/MS grade. Do you think that would be the problem also?
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