Do you want to remove the glycan while lectin is still bound or you want to remove lectin altogether with the cell? I worked extensively on glycan-lectin interaction but using ESI MS.

Thank you for your answer. I need to remove only the lectin and have the glycan still functional. Do you think that lectin binding can be reversible?

Of course, lectin binding is reversible. You only have to use a competitor (for instance free sugar) in a concentration large enough to break the interaction, then wash your cells in order to get rid of the lectin and competitor .

Thank you!