Dear all, please could you help me? I have a small molecule with N-Boc protected and a vinyl methyl ketone portion. So, now I would like to remove the Boc, in order to obtain the free amine. I tried some experiments with TFA in DCM without success. Please, could you share with me your experiences, your opinions, your suggestions? Thanks in advance
Dear Santo, you could dissolve the molecule in methanol (50 mL) and add TMSCl (5 mL). The small amounts of HCl can deprotect the amine. Maybe you have to heat it gentle (40 °C). Hope that helps.
Hi- Normally TFA in DCM works, but you might also find this paper workable for your compound.
Article Mild deprotection of the N-tert -butyloxycarbonyl ( N -Boc) ...
Dear santo,you can remove N- boc in excess boiling water at 100 C (373 K).
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