My compound is only soluble in MeOH, This is LAH reduction reaction from ester to alcohol, after reaction completion, LAH is quenched by water and MeOH, the compound is extracted with soxhlet extraction but I got more white solid. even I tried this extraction with MeOH stirring at reflux temp and filtered, got the same white solid.
Dear Sharad,
one way to remove Al(OH)3 formed after quenching a LAH reduction reaction is to filtered your reaction suspension on a celite pad. Obviously, assuming that your product is soluble in the reaction suspension. Al(OH)3 passes paper filter.
Sir,
I use to filter reaction suspension on a celite pad only, but Al(OH)3 or Al(OMe)3 passes with solvent, when I evaporate solvent I got white solid in excess
Respected sir,
you can try with saturated aqueous solution of Rochelle's salt (sodium potassium tartrate). Rochelle's salt is an excellent ligand for aluminium and breaks the aluminium emulsion. The procedure is simple. Cool your finished reduction down to 0 degrees C, or lower depending on the situation (cooled it with acetone/dry ice).quench excess reducing agent with ethyl acetate or acetone. Add a water solution of rochelle's salt ( 3-5 mol equiv rochelle, and calculate the amount of water from there). Let the temperature rise to r.t. and stirr for 30 minutes or longer if necessary.extract ur mixture using EA or ether and evaporated it. Hope u get better results.
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology
- Antibodies