I am using Delft3d model, for one case in the simulation time was 3 days but then it increases and now it became 42 days how to solve this problem and how can I reduce the simulation time?
Excluding the software limitations you may try to simplify your analytical posing. Although, of course, the problem you are dealing with may not be reducible. If this is the case you may consider a parallel programing or so. I had problems like that (simulation time of the order of 3-4 days) with the COMSOL-MATLAB-SIMULINK coupling (and I had already simplified the posing!). I did not use parallel programming but I have to simplify the problem.
What is the difference between the case you simulated in 3 days and the case that needed 42 days? The key of your problem is there. You probably had a longer simulation period or changed the grid (higher resolution) or added some processes, etc.
In general, it is useful to make the grid coarser and increase the computational time step.