Block the chemical bond to which hydrolysis targets !

Dear all, your actual problem occurs while doing thermal evaporation. You can evaporate under reduced pressure at the lowest possible température, but the best will be freeze-drying. My Regards

Lassaad Hedhili Thanks but how, any chemical you can recommend which will be biocompatible also??

Thanks Abdelkader BOUAZIZ ... you mean its getting hydrolysed during evaporation stage..not during mixing......but i am not giving any temprature, I am evaporating it on room temperature under continuous stirring.... should I go for rotary evaporation??? Or could the probe sonication be the reason? Though i perform sonication for mixing both phases upon ice.....

Could pH be the factor.. its 5.5....... may be due to tween???

How much time does it take to evaporate at room temperature? This time if too long it adds in favor of hydrolysis. Yes, rotavap is to be used at reduced pressure and low bath temperature. Best of Luck

Abdelkader BOUAZIZ it takes three hours for evaporation..........

Too long if it is to avoid or reduce hydrolysis. Try the rotavap. Good Luck

This RG link provides a document on the pH effect. My Regards

https://www.researchgate.net/publication/231374878_Effect_of_pH_on_Ether_Ester_and_Carbonate_Hydrolysis_in_High-Temperature_Water

Thanksss alotttt...........Abdelkader BOUAZIZ

Hi;

The conversion degree of carboxylic acid and the esterification degree depend on the temperature and the reaction time as well as the glycerol/sebacate ratio.

With my best regards

Dear Ramish Riaz;

Please see attached document for further details.

With my best regards