Hello,
I am looking to produce a set of two scfv fused to an IgG2a (to dimerize it) but I know that there can be aggregation problems, between the two scfv and also between the VH and VL of the scfv. So I wanted to know if there was a bioinformatics tool to predict aggregations.
I thank you for your help.
Marcelo Brigido
You can try to predict aggregation potential and aggregation-prone sequences using Tango or Waltz. A compilation of aggregation prediction algorithms can be found at https://switchlab.org/software/
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Judith Weber
Thanks a lot for your answer Marcelo Brigido . I am looking for something for a while. I will take a look.
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