How to overcome the effect of read counts on TCR repertoire overlap/diversity analysis?

Kaifeng Hung @Kaifeng-Hung

01 November 2021 0 6K Report

Dear All,

We have multiple TCR sequencing data that vary in sequencing depth (with different read counts).

May I know how I can overcome the effect of read counts on TCR repertoire diversity/overlap analysis?

Thank you,

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