As medical advances are made in the care of patients with chronic diseases including those with (ESRD), patients are not only experiencing increasing life expectancy but also bearing the burden of illness and treatment methods for a long duration of time. Therefore, it is important for health care providers to pay more attention to their individual patient's perceptions of their life satisfaction, health, fitness, and well-being. Health-Related Quality of Life (HRQOL includes an evaluation of the patient's level of satisfaction with treatment, outcome, and health status, also taking into account their perspective on future prospects. How we can measurably improve health-related quality of life in hemodialysis patients?