I have a set of populations that have been tested against multiple pesticide doses which show dose-response curve with a large plateau in the middle. I usually use R package drc but drc does not seem to have a biphasic curve option. I tried package mixtox with function CurveFit which has a biphasic model but cannot find how to fit multiple populations at the same time or add different models to the same plot. The option biphasic is also in GraphPrism but I am trying to avoid this software. For the moment, I divided my data in 2 (on both side of the plateau) and fitted LL3 but the plotting of these on the same plot is quite messy to say the least.
Hi dear friend The best tool for doing a response analysis is the Graphpad prism application.
Analyze / Nonlinear regression / dose-response - Special / Biphasic
Thanks Abolfazl, you're right; I ended up using GraphPad prism. I would love to be able to do it in R using drc package but I don't think there is any implementation yet.
CurvFit™ is a (free) curve fitting program for Windows. Lorentzian, Sine, Exponential and Power series are available models to match your data. A Lorentzian series is highly recommended for real data especially for multiple peaked and/or valleys data. Download at http://fortranCalculus.info/apps/curvfit.html
Make your own 'xxx' series: have a function you want to try? See the CurvFit's source code (included in CurvFit-install.exe) ... fit4user.fc file. Their are 6 series as of this writing. Modify or add one to fit your function. Download the free FC-Compiler™ that you will need to re-compile your version of CurvFit.
For more, see https://www.researchgate.net/publication/330367309_CurvFit_a_Curve_Fitting_Windows_Application
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